دوره 27، شماره 1 - ( بهار 1400 )                   جلد 27 شماره 1 صفحات 91-78 | برگشت به فهرست نسخه ها

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Arzanlou M, Armanikian A, Saed O, Dobakhti F, Motamed N, Ahmadiafshar A. Accuracy of Niacin Skin Flush Test for Diagnosing Schizophrenia. IJPCP 2021; 27 (1) :78-91
URL: http://ijpcp.iums.ac.ir/article-1-3044-fa.html
ارزنلو محمد، آرمانی کیان علیرضا، ساعد امید، دوبختی فرامرز، معتمد نیما، احمدی افشار عاکفه. تعیین ارزش پیش‌بینی‌کنندگی تست حساسیت پوستی نیاسین برای تشخیص بیماری اسکیزوفرنیا. مجله روانپزشكي و روانشناسي باليني ايران. 1400; 27 (1) :78-91

URL: http://ijpcp.iums.ac.ir/article-1-3044-fa.html

تعیین ارزش پیش‌بینی‌کنندگی تست حساسیت پوستی نیاسین برای تشخیص بیماری اسکیزوفرنیا
محمد ارزنلو 1، علیرضا آرمانی کیان2 ، امید ساعد3 ، فرامرز دوبختی3 ، نیما معتمد4 ، عاکفه احمدی افشار5
1- گروه روانپزشکی، دانشکده پزشکی، دانشگاه علوم‌پزشکی زنجان، زنجان، ایران. ، darmangar52@gmail.com
2- گروه روانپزشکی، بیمارستان بهشتی، دانشگاه علوم‌پزشکی زنجان، زنجان، ایران.
3- گروه روانشناسی بالینی، دانشکده پزشکی، دانشگاه علوم‌پزشکی زنجان، زنجان ایران.
4- گروه پزشکی اجتماعی، دانشکده پزشکی، دانشگاه علوم‌پزشکی زنجان، زنجان، ایران.
5- گروه اطفال، بیمارستان آیت‌الله موسوی، دانشگاه علوم‌پزشکی زنجان، زنجان، ایران.
چکیده:   (2741 مشاهده)
اهداف: این مطالعه برای ارزیابی پاسخ حساسیت پوستی در اثر تماس با محلول نیاسین در بیماران مبتلا به اسکیزوفرنیا وگروه کنترل سالم برای بررسی صحت استفاده از این تست در کمک به تشخیص و غربالگری بیماران مبتلا به اسکیزوفرنیا انجام شد.
مواد و روش ها: این مطالعه از نوع ارزیابی تست‌های تشخیصی است که در سال 1397 در شهرستان زنجان انجام شد. افراد شرکت‌کننده در این مطالعه شامل 157 نفر بیمار شناسایی‌شده مبتلا به اسکیزوفرنیا بودند که اساتید روان‌پزشکی آن‌ها را معرفی کرده بودند و همچنین 33 نفر در قالب گروه کنترل غیربیمار وارد مطالعه شدند. با توجه به معیارهای خروج از 157 بیمار تنها 36 نفر وارد مطالعه شدند. کارشناسان غیرمطلع از وضعیت بیمار آزمون حساسیت به نیاسین را با استفاده از محلول متیل نیکونینات (شرکت سیگما آلدریچ با خلوص بالای 99 درصد) با غلظت‌های گوناگون 0/1، 0/01 و 0/001 مول و به طور جداگانه با در نظر گرفتن بازه‌های زمانی متفاوت (10،5، 15 و20 دقیقه) انجام دادند. حساسیت، ویژگی، ارزش اخباری مثبت و ارزش اخباری منفی محاسبه و گزارش شد. 
یافته ها: در 10 دقیقه ، بالاترین دقت آزمون هنگام استفاده از محلول نیاسین0/001 میلی متر گزارش شد (حساسیت = 94 درصد، ویژگی =50 درصد، PPV = 51درصد، و NPV = 94 درصد)؛ در 15 دقیقه، بالاترین دقت آزمون در غلظت 0/01 مشاهده شد (حساسیت = 52 درصد، ویژگی = 77 درصد،79 = PPV درصد، NPV = 77درصد).
نتیجه گیری: پاسخ واکنشی پوست در برابر نیاسین در میان افراد دارای تشخیص اسکیزوفرنیا ضعیف و یا خنثی‌شده است. بنابراین، استفاده از این ماده یک بیومارکر تکمیلی در کمک به تشخیص و غربالگری اسکیزوفرنیا و زمینه مناسبی برای کارهای تحقیقی است.
واژه‌های کلیدی: اسکیزوفرنیا، نیاسین، حساسیت، ویژگی، ارزش پیش‌بینی‌کنندگی تست
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نوع مطالعه: پژوهشي اصيل | موضوع مقاله: روانپزشکی و روانشناسی
دریافت: 1398/4/12 | پذیرش: 1399/5/29 | انتشار: 1400/1/31
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