دوره 27، شماره 1 - ( بهار 1400 )                   جلد 27 شماره 1 صفحات 91-78 | برگشت به فهرست نسخه ها


XML English Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Arzanlou M, Armanikian A, Saed O, Dobakhti F, Motamed N, Ahmadiafshar A. Accuracy of Niacin Skin Flush Test for Diagnosing Schizophrenia. IJPCP 2021; 27 (1) :78-91
URL: http://ijpcp.iums.ac.ir/article-1-3044-fa.html
ارزنلو محمد، آرمانی کیان علیرضا، ساعد امید، دوبختی فرامرز، معتمد نیما، احمدی افشار عاکفه. تعیین ارزش پیش‌بینی‌کنندگی تست حساسیت پوستی نیاسین برای تشخیص بیماری اسکیزوفرنیا. مجله روانپزشكي و روانشناسي باليني ايران. 1400; 27 (1) :78-91

URL: http://ijpcp.iums.ac.ir/article-1-3044-fa.html


1- گروه روانپزشکی، دانشکده پزشکی، دانشگاه علوم‌پزشکی زنجان، زنجان، ایران. ، darmangar52@gmail.com
2- گروه روانپزشکی، بیمارستان بهشتی، دانشگاه علوم‌پزشکی زنجان، زنجان، ایران.
3- گروه روانشناسی بالینی، دانشکده پزشکی، دانشگاه علوم‌پزشکی زنجان، زنجان ایران.
4- گروه پزشکی اجتماعی، دانشکده پزشکی، دانشگاه علوم‌پزشکی زنجان، زنجان، ایران.
5- گروه اطفال، بیمارستان آیت‌الله موسوی، دانشگاه علوم‌پزشکی زنجان، زنجان، ایران.
چکیده:   (2391 مشاهده)
اهداف: این مطالعه برای ارزیابی پاسخ حساسیت پوستی در اثر تماس با محلول نیاسین در بیماران مبتلا به اسکیزوفرنیا وگروه کنترل سالم برای بررسی صحت استفاده از این تست در کمک به تشخیص و غربالگری بیماران مبتلا به اسکیزوفرنیا انجام شد.
مواد و روش ها: این مطالعه از نوع ارزیابی تست‌های تشخیصی است که در سال 1397 در شهرستان زنجان انجام شد. افراد شرکت‌کننده در این مطالعه شامل 157 نفر بیمار شناسایی‌شده مبتلا به اسکیزوفرنیا بودند که اساتید روان‌پزشکی آن‌ها را معرفی کرده بودند و همچنین 33 نفر در قالب گروه کنترل غیربیمار وارد مطالعه شدند. با توجه به معیارهای خروج از 157 بیمار تنها 36 نفر وارد مطالعه شدند. کارشناسان غیرمطلع از وضعیت بیمار آزمون حساسیت به نیاسین را با استفاده از محلول متیل نیکونینات (شرکت سیگما آلدریچ با خلوص بالای 99 درصد) با غلظت‌های گوناگون 0/1، 0/01 و 0/001 مول و به طور جداگانه با در نظر گرفتن بازه‌های زمانی متفاوت (10،5، 15 و20 دقیقه) انجام دادند. حساسیت، ویژگی، ارزش اخباری مثبت و ارزش اخباری منفی محاسبه و گزارش شد. 
یافته ها: در 10 دقیقه ، بالاترین دقت آزمون هنگام استفاده از محلول نیاسین0/001 میلی متر گزارش شد (حساسیت = 94 درصد، ویژگی =50 درصد، PPV = 51درصد، و NPV = 94 درصد)؛ در 15 دقیقه، بالاترین دقت آزمون در غلظت 0/01 مشاهده شد (حساسیت = 52 درصد، ویژگی = 77 درصد،79 = PPV درصد، NPV = 77درصد).
نتیجه گیری: پاسخ واکنشی پوست در برابر نیاسین در میان افراد دارای تشخیص اسکیزوفرنیا ضعیف و یا خنثی‌شده است. بنابراین، استفاده از این ماده یک بیومارکر تکمیلی در کمک به تشخیص و غربالگری اسکیزوفرنیا و زمینه مناسبی برای کارهای تحقیقی است.
متن کامل [PDF 6039 kb]   (994 دریافت) |   |   متن کامل (HTML)  (1776 مشاهده)  
نوع مطالعه: پژوهشي اصيل | موضوع مقاله: روانپزشکی و روانشناسی
دریافت: 1398/4/12 | پذیرش: 1399/5/29 | انتشار: 1400/1/31

فهرست منابع
1. Association AP. Diagnostic and statistical manual of mental disorders. BMC Med. 2013;17:133-7.
2. Conti C, Lanzara R, Scipioni M, Iasenza M, Guagnano MT, Fulcheri M. The Relationship between Binge Eating Disorder and Suicidality: A Systematic Review. Frontiers in psychology. 2017;8:2125-. [DOI:10.3389/fpsyg.2017.02125] [PMID] [PMCID]
3. Trace SE, Thornton LM, Runfola CD, Lichtenstein P, Pedersen NL, Bulik CM. Sleep problems are associated with binge eating in women. International Journal of Eating Disorders. 2012;45(5):695-703. [DOI:10.1002/eat.22003] [PMID] [PMCID]
4. Succurro E, Segura-Garcia C, Ruffo M, Caroleo M, Rania M, Aloi M, et al. Obese patients with a binge eating disorder have an unfavorable metabolic and inflammatory profile. Medicine. 2015;94(52). [DOI:10.1097/MD.0000000000002098] [PMID] [PMCID]
5. Mitchell JE, King WC, Pories W, Wolfe B, Flum DR, Spaniolas K, et al. Binge eating disorder and medical comorbidities in bariatric surgery candidates. International Journal of Eating Disorders. 2015;48(5):471-6. [DOI:10.1002/eat.22389] [PMID] [PMCID]
6. Cremonini F, Camilleri M, Clark MM, Beebe T, Locke G, Zinsmeister A, et al. Associations among binge eating behavior patterns and gastrointestinal symptoms: a population-based study. International journal of obesity. 2009;33(3):342-53. [DOI:10.1038/ijo.2008.272] [PMID] [PMCID]
7. Agh T, Kovács G, Supina D, Pawaskar M, Herman BK, Vokó Z, et al. A systematic review of the health-related quality of life and economic burdens of anorexia nervosa, bulimia nervosa, and binge eating disorder. Eating and Weight Disorders-Studies on Anorexia, Bulimia and Obesity. 2016;21(3):353-64. [DOI:10.1007/s40519-016-0264-x] [PMID] [PMCID]
8. Agh T, Kovács G, Pawaskar M, Supina D, Inotai A, Vokó Z. Epidemiology, health-related quality of life and economic burden of binge eating disorder: a systematic literature review. Eating and Weight Disorders-Studies on Anorexia, Bulimia and Obesity. 2015;20(1):1-12. [DOI:10.1007/s40519-014-0173-9] [PMID] [PMCID]
9. Bulik CM, Reichborn‐Kjennerud T. Medical morbidity in binge eating disorder. International Journal of Eating Disorders. 2003;34(S1):S39-S46. [DOI:10.1002/eat.10204] [PMID]
10. Javaras KN, Pope Jr HG, Lalonde JK, Roberts JL, Nillni YI, Laird NM, et al. Co-occurrence of binge eating disorder with psychiatric and medical disorders. The Journal of clinical psychiatry. 2008. [DOI:10.4088/JCP.v69n0213] [PMID]
11. Bertoli S, Leone A, Ponissi V, Bedogni G, Beggio V, Strepparava MG, et al. Prevalence of and risk factors for binge eating behaviour in 6930 adults starting a weight loss or maintenance programme. Public health nutrition. 2016;19(1):71-7. [DOI:10.1017/S1368980015001068] [PMID]
12. Strine TW, Mokdad AH, Dube SR, Balluz LS, Gonzalez O, Berry JT, et al. The association of depression and anxiety with obesity and unhealthy behaviors among community-dwelling US adults. General hospital psychiatry. 2008;30(2):127-37. [DOI:10.1016/j.genhosppsych.2007.12.008] [PMID]
13. Munsch S, Meyer AH, Quartier V, Wilhelm FH. Binge eating in binge eating disorder: a breakdown of emotion regulatory process? Psychiatry research. 2012;195(3):118-24. [DOI:10.1016/j.psychres.2011.07.016] [PMID]
14. Gratz KL, Roemer L. Multidimensional assessment of emotion regulation and dysregulation: Development, factor structure, and initial validation of the difficulties in emotion regulation scale. Journal of psychopathology and behavioral assessment. 2004;26(1):41-54. [DOI:10.1023/B:JOBA.0000007455.08539.94]
15. Yap MB, Allen NB, Sheeber L. Using an emotion regulation framework to understand the role of temperament and family processes in risk for adolescent depressive disorders. Clinical child and family psychology review. 2007;10(2):180-96. [DOI:10.1007/s10567-006-0014-0] [PMID]
16. Leehr EJ, Krohmer K, Schag K, Dresler T, Zipfel S, Giel KE. Emotion regulation model in binge eating disorder and obesity-a systematic review. Neuroscience & Biobehavioral Reviews. 2015;49:125-34. [DOI:10.1016/j.neubiorev.2014.12.008] [PMID]
17. Appelhans BM, Whited MC, Schneider KL, Oleski J, Pagoto SL. Response style and vulnerability to anger-induced eating in obese adults. Eating Behaviors. 2011;12(1):9-14. [DOI:10.1016/j.eatbeh.2010.08.009] [PMID] [PMCID]
18. Lemmens SG, Rutters F, Born JM, Westerterp-Plantenga MS. Stress augments food 'wanting'and energy intake in visceral overweight subjects in the absence of hunger. Physiology & behavior. 2011;103(2):157-63. [DOI:10.1016/j.physbeh.2011.01.009] [PMID]
19. Rosenberg N, Bloch M, Avi IB, Rouach V, Schreiber S, Stern N, et al. Cortisol response and desire to binge following psychological stress: Comparison between obese subjects with and without binge eating disorder. Psychiatry Research. 2013;208(2):156-61. [DOI:10.1016/j.psychres.2012.09.050] [PMID]
20. McManus F, Waller G. A functional analysis of binge-eating. Clinical psychology review. 1995;15(8):845-63. [DOI:10.1016/0272-7358(95)00042-9]
21. Agras WS, Rossiter EM, Arnow B, Telch CF, Raeburn SD, Bruce B, et al. One-year follow-up of psychosocial and pharmacologic treatments for bulimia nervosa. Journal of Clinical Psychiatry. 1994.
22. Wilfley D, Crow S, Hudson J, Mitchell J, Berkowitz R, Blakesley V, et al. Sibutramine Binge Eating Disorder Research Group: Efficacy of sibutramine for the treatment of binge eating disorder: a randomized multicenter placebo-controlled double-blind study. Am J Psychiatry. 2008;165(1):51-8. [DOI:10.1176/appi.ajp.2007.06121970] [PMID]
23. Grilo CM, Masheb RM, Wilson GT. Efficacy of cognitive behavioral therapy and fluoxetine for the treatment of binge eating disorder: a randomized double-blind placebo-controlled comparison. Biological psychiatry. 2005;57(3):301-9. [DOI:10.1016/j.biopsych.2004.11.002] [PMID]
24. Latner J, Stunkard A, Wilson G, Jackson M, Zelitch D, Labouvie E. Effective long-term treatment of obesity: a continuing care model. International Journal of Obesity & Related Metabolic Disorders. 2000;24(7). [DOI:10.1038/sj.ijo.0801249] [PMID]
25. Wilson GT, Fairburn CC, Agras WS, Walsh BT, Kraemer H. Cognitive-behavioral therapy for bulimia nervosa: Time course and mechanisms of change. Journal of consulting and clinical psychology. 2002;70(2):267. [DOI:10.1037/0022-006X.70.2.267] [PMID]
26. Carter JC, Fairburn CG. Cognitive-behavioral self-help for binge eating disorder: A controlled effectiveness study. Journal of Consulting and Clinical Psychology. 1998;66(4):616. [DOI:10.1037/0022-006X.66.4.616]
27. Wilfley DE, Welch RR, Stein RI, Spurrell EB, Cohen LR, Saelens BE, et al. A randomized comparison of group cognitive-behavioral therapy and group interpersonal psychotherapy for the treatment of overweight individuals with binge-eating disorder. Archives of general psychiatry. 2002;59(8):713-21. [DOI:10.1001/archpsyc.59.8.713] [PMID]
28. Safer DL, Jo B. Outcome from a randomized controlled trial of group therapy for binge eating disorder: comparing dialectical behavior therapy adapted for binge eating to an active comparison group therapy. Behavior Therapy. 2010;41(1):106-20. [DOI:10.1016/j.beth.2009.01.006] [PMID] [PMCID]
29. Telch CF, Agras WS, Linehan MM. Group dialectical behavior therapy for binge-eating disorder: A preliminary, uncontrolled trial. Behavior Therapy. 2000;31(3):569-82. [DOI:10.1016/S0005-7894(00)80031-3]
30. Marcus M, Wing R, Fairburn C. Cognitive treatment of binge eating versus behavioral weight control in the treatment of binge eating disorder. Annals of Behavioral Medicine. 1995;17:S090.
31. Wilson GT. Treatment of binge eating disorder. Psychiatric Clinics. 2011;34(4):773-83. [DOI:10.1016/j.psc.2011.08.011] [PMID]
32. Association AP. American Psychiatric Association Practice Guidelines for the treatment of psychiatric disorders: compendium 2006: American Psychiatric Pub; 2006.
33. Whiteside U, Chen E, Neighbors C, Hunter D, Lo T, Larimer M. Difficulties regulating emotions: Do binge eaters have fewer strategies to modulate and tolerate negative affect? Eating behaviors. 2007;8(2):162-9. [DOI:10.1016/j.eatbeh.2006.04.001] [PMID]
34. Ricca V, Castellini G, Sauro CL, Ravaldi C, Lapi F, Mannucci E, et al. Correlations between binge eating and emotional eating in a sample of overweight subjects. Appetite. 2009;53(3):418-21. [DOI:10.1016/j.appet.2009.07.008] [PMID]
35. Rice LN. Patterns of change: Intensive analysis of psychotherapy process: Guilford Press; 1984.
36. Greenberg LS, Safran JD. Emotion in psychotherapy. American psychologist. 1989;44(1):19. [DOI:10.1037/0003-066X.44.1.19]
37. Greenberg LS. Emotion-focused therapy: A clinical synthesis. Focus. 2010;8(1):32-42. [DOI:10.1176/foc.8.1.foc32]
38. Elliott R, Watson JC, Goldman RN, Greenberg LS. Learning emotion-focused therapy: The process-experiential approach to change: American Psychological Association; 2004. [DOI:10.1037/10725-000]
39. Rice LN, Elliott R. Facilitating emotional change: The moment-by-moment process: Guilford Press; 1996.
40. Elliott R. Emotion-focused therapy. In: The tribes of the person-centred nation. PCCS Books, Ross-on-Wye, pp. 2012;103-130(. ISBN 9781906254551).
41. Wnuk SM, Greenberg L, Dolhanty J. Emotion-focused group therapy for women with symptoms of bulimia nervosa. Eating disorders. 2015;23(3):253-61. [DOI:10.1080/10640266.2014.964612] [PMID]
42. Lafrance Robinson A, McCague EA, Whissell C. "That chair work thing was great": a pilot study of group-based emotion-focused therapy for anxiety and depression. Person-Centered & Experiential Psychotherapies. 2014;13(4):263-77. [DOI:10.1080/14779757.2014.910131]
43. Tasca GA, Bone M. Individual versus group psychotherapy for eating disorders. International Journal of Group Psychotherapy. 2007;57(3):399-403. [DOI:10.1521/ijgp.2007.57.3.399] [PMID]
44. Gormally J, Black S, Daston S, Rardin D. The assessment of binge eating severity among obese persons. Addictive behaviors. 1982;7(1):47-55. [DOI:10.1016/0306-4603(82)90024-7]
45. Mootabi F, Moloodi R, Dezhkam M, Omidvar N. Standardization of the binge eating scale among Iranian Obese population. Iranian Journal of Psychiatry. 2009;4(4):143-6.
46. Asgari P, PASHA GR, Aminiyan M. Relationship between emotion regulation, mental stresses and body image with eating disorders of women. 2009.
47. Beck AT, Epstein N, Brown G, Steer RA. An inventory for measuring clinical anxiety: psychometric properties. Journal of consulting and clinical psychology. 1988;56(6):893. [DOI:10.1037/0022-006X.56.6.893] [PMID]
48. Kaviani H, Mousavi A. Psychometric properties of the Persian version of Beck Anxiety Inventory (BAI). Tehran University Medical Journal TUMS Publications. 2008;66(2):136-40.
49. Richter P, Werner J, Heerlein A, s e, Kraus A, Sauer H. On the validity of the Beck Depression Inventory. Psychopathology. 1998;31(3):160-8. [DOI:10.1159/000066239] [PMID]
50. Goudarzi M. The study of reliability and validity of Beck hopelessness scale in a group of Shiraz university students. 2002.
51. Ivanova I. The" How" of Change in Emotion-focused Group Therapy for Eating Disorders 2013.
52. Compare A, Calugi S, Marchesini G, Shonin E, Grossi E, Molinari E, et al. Emotionally focused group therapy and dietary counseling in binge eating disorder. Effect on eating disorder psychopathology and quality of life. Appetite. 2013;71:361-8. [DOI:10.1016/j.appet.2013.09.007] [PMID]
53. Beumont PJ, Garner D, Touyz SW. Comments on the proposed criteria for eating disorders in DSM IV. European Eating Disorders Review. 1994;2(2):63-75. [DOI:10.1002/erv.2400020203]
54. De Jonge PVH, Van Furth E, Lacey JH, Waller G. The prevalence of DSM-IV personality pathology among individuals with bulimia nervosa, binge eating disorder and obesity. Psychological medicine. 2003;33(7):1311-7. [DOI:10.1017/S0033291703007505] [PMID]
55. Schulz S, Laessle R. Stress-induced laboratory eating behavior in obese women with binge eating disorder. Appetite. 2012;58(2):457-61. [DOI:10.1016/j.appet.2011.12.007] [PMID]
56. Svaldi J, Caffier D, Tuschen-Caffier B. Emotion suppression but not reappraisal increases desire to binge in women with binge eating disorder. Psychotherapy and psychosomatics. 2010;79(3):188-90. [DOI:10.1159/000296138] [PMID]
57. Greenberg LS, Pascual‐Leone A. Emotion in psychotherapy: A practice‐friendly research review. Journal of clinical psychology. 2006;62(5):611-30. [DOI:10.1002/jclp.20252] [PMID]
58. Watson JC. The process of growth and transformation: Extending the process model. Person-Centered & Experiential Psychotherapies. 2011;10(1):11-27. [DOI:10.1080/14779757.2011.564760]
59. Shahar B. Emotion‐Focused Therapy for the Treatment of Social Anxiety: An Overview of the Model and a Case Description. Clinical psychology & psychotherapy. 2014;21(6):536-47. [DOI:10.1002/cpp.1853] [PMID]
60. Greenberg L, Watson J. Experiential therapy of depression: Differential effects of client-centered relationship conditions and process experiential interventions. Psychotherapy Research. 1998;8(2):210-24. [DOI:10.1093/ptr/8.2.210]
61. Goldman RN, Greenberg LS, Angus L. The effects of adding emotion-focused interventions to the client-centered relationship conditions in the treatment of depression. Psychotherapy Research. 2006;16(5):537-49. [DOI:10.1080/10503300600589456]
62. Greenberg LS, Watson JC. Emotion-focused therapy for depression: American Psychological Association; 2006. [DOI:10.1037/11286-000]
63. Rieger E, Van Buren DJ, Bishop M, Tanofsky-Kraff M, Welch R, Wilfley DE. An eating disorder-specific model of interpersonal psychotherapy (IPT-ED): Causal pathways and treatment implications. Clinical Psychology Review. 2010;30(4):400-10. [DOI:10.1016/j.cpr.2010.02.001] [PMID]
64. Apple RF. . Interpersonal psychotherapy for bulimia nervosa. Journal of Clinical Psychology,. 1999;55, 715-725. https://doi.org/10.1002/(SICI)1097-4679(199906)55:6<715::AID-JCLP5>3.0.CO;2-B [DOI:10.1002/(SICI)1097-4679(199906)55:63.0.CO;2-B]
65. Angus LE, and Leslie S. Greenberg. Working with narrative in emotion-focused therapy: Changing stories, healing lives. . American Psychological Association. , 2011. [DOI:10.1037/12325-000]
66. Bydlowski S, Corcos, M., Jeammet, P., Paterniti, S., Berthoz, S., Laurier, C., ... & Consoli, S. M. Emotion‐processing deficits in eating disorders. International Journal of Eating Disorders. 2005;37(4), 321-329.‏. [DOI:10.1002/eat.20132] [PMID]
67. Heatherton TF, & Baumeister, R.F. . Binge eating as escape from self-awareness. Psychological Bulletin. 1991;110, 86-108. [DOI:10.1037/0033-2909.110.1.86] [PMID]
68. Dolhanty J, Greenberg LS. Emotion-focused therapy in the treatment of eating disorders. European Psychotherapy. 2007;7(1):97-116.
69. Greenberg L. motion and cognition in psychotherapy: The transforming power of affect. Canadian Psychology/Psychologie Canadienne. 2008;doi:10.1037/0708-5591.49.1. [DOI:10.1037/0708-5591.49.1.49]

ارسال نظر درباره این مقاله : نام کاربری یا پست الکترونیک شما:
CAPTCHA

بازنشر اطلاعات
Creative Commons License این مقاله تحت شرایط Creative Commons Attribution-NonCommercial 4.0 International License قابل بازنشر است.

کلیه حقوق این وب سایت متعلق به مجله روانپزشکی و روانشناسی بالینی ایران می باشد.

طراحی و برنامه نویسی : یکتاوب افزار شرق

© 2024 CC BY-NC 4.0 | Iranian Journal of Psychiatry and Clinical Psychology

Designed & Developed by : Yektaweb