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Volume 27, Issue 1 (Spring 2021)
IJPCP 2021, 27(1): 78-91 |
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Arzanlou M, Armanikian A, Saed O, Dobakhti F, Motamed N, Ahmadiafshar A. Accuracy of Niacin Skin Flush Test for Diagnosing Schizophrenia. IJPCP 2021; 27 (1) :78-91
URL: http://ijpcp.iums.ac.ir/article-1-3044-en.html
URL: http://ijpcp.iums.ac.ir/article-1-3044-en.html
Mohammad Arzanlou 
1, Alireza Armanikian2 , Omid Saed3 , Faramarz Dobakhti4 , Nima Motamed5 , Akefeh Ahmadiafshar6
1, Alireza Armanikian2 , Omid Saed3 , Faramarz Dobakhti4 , Nima Motamed5 , Akefeh Ahmadiafshar6
1- Department of Psychiatry, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran. , darmangar52@gmail.com
2- Department of Psychiatry, Shahid Beheshti Hospital, Zanjan University of Medical Sciences, Zanjan, Iran.
3- Department of Clinical Psychology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.
4- Department of Pharmaceutics, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran.
5- Department of Community Medicine, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.
6- Department of Pediatrics, Ayatollah Mousavi Hospital, Zanjan University of Medical Sciences, Zanjan, Iran.
2- Department of Psychiatry, Shahid Beheshti Hospital, Zanjan University of Medical Sciences, Zanjan, Iran.
3- Department of Clinical Psychology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.
4- Department of Pharmaceutics, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran.
5- Department of Community Medicine, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.
6- Department of Pediatrics, Ayatollah Mousavi Hospital, Zanjan University of Medical Sciences, Zanjan, Iran.
Abstract: (2740 Views)
Objectives: This study aims to investigate niacin sensitivity in schizophrenia patients compared to healthy people and examine the accuracy of niacin skin flush test in diagnosing schizophrenia.
Methods: This diagnostic study was conducted in 2018 in Zanjan, Iran. Three niacin concentrations (0.001 M, 0.01 M, and 0.1 M) was first applied topically to the skin of 36 schizophrenia patients and 33 healthy controls. Flush responses were evaluated at 10 and 15 min after application. Sensitivity, specificity, Positive Predictive Value (PPV), and Negative Predictive Value (NPV) of the test were measured for each niacin concentration and evaluation time.
Results: At 10 min, the highest test accuracy was reported when 0.001 M niacin solution was used (Sensitivity=94%, specificity=50%, PPV= 51%, and NPV= 94%). At 15 min, the highest test accuracy was observed at 0.01 concentration (Sensitivity=52%, specificity=92%, PPV=79%, and NPV=77%).
Conclusion: Flush responses to niacin is more impaired in patients with schizophrenia. Therefore, niacin can be considered as a biological marker of schizophrenia and can be used for its diagnosis.
Methods: This diagnostic study was conducted in 2018 in Zanjan, Iran. Three niacin concentrations (0.001 M, 0.01 M, and 0.1 M) was first applied topically to the skin of 36 schizophrenia patients and 33 healthy controls. Flush responses were evaluated at 10 and 15 min after application. Sensitivity, specificity, Positive Predictive Value (PPV), and Negative Predictive Value (NPV) of the test were measured for each niacin concentration and evaluation time.
Results: At 10 min, the highest test accuracy was reported when 0.001 M niacin solution was used (Sensitivity=94%, specificity=50%, PPV= 51%, and NPV= 94%). At 15 min, the highest test accuracy was observed at 0.01 concentration (Sensitivity=52%, specificity=92%, PPV=79%, and NPV=77%).
Conclusion: Flush responses to niacin is more impaired in patients with schizophrenia. Therefore, niacin can be considered as a biological marker of schizophrenia and can be used for its diagnosis.
Type of Study: Original Research |
Subject:
Psychiatry and Psychology
Received: 2019/07/3 | Accepted: 2020/08/19 | Published: 2021/04/20
Received: 2019/07/3 | Accepted: 2020/08/19 | Published: 2021/04/20
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