Objective: this study has been carried out in Iran and Tehran Universities of Medical Sciences to assess the relationship among stressors, the rate of reliance on God and stress symptoms. Method: the 408 study sample (M=234, F=174), were randomly selected from the students, with the age mean score 22.4 years old (SD= 3.45), studying in different educational levels of basic sciences, physiopathology, clinical and internships. The data were collected through "Reliance on God Questionnaire", "Stressors Questionnaire", and "stress symptoms questionnaire", and were statistically analyzed by variance, and Sheffe's methods. Findings: the findings showed that 44.1% of the subjects had low level of stress, 31.1% had average level and 24.8% had high level of stress. The stressors like failing in exams, death of the beloved ones, and severe fights with father, gained the highest percentile rate among the students respectively. From the symptoms, distress, anxiety and shyness are reported more than any other symptoms by the subjects. Results: the comparisons between the scores obtained from the two scales indicated that the higher the scores of "reliance on God Questionnaire" results a decrease of the scores in "Stress Symptoms Questionnaire".