Objectives: The Present study was designed to investigate differences between paranoid and non-paranoid diagnosed patients in their soft neurological signs (SNS). The relationship between SNS and medication used for psychiatric treatment of the disorder was also noted. Method: Forty patients with diagnosis of schizophrenia (20 males and 20 females) and 15 subjects without any psychiatric disorder were asked to participate in the study. There were equal numbers of patients with diagnosis of paranoid and other subtypes of schizophrenia (non-paranoid). The patients were interviewed and examined for SNS individually. The dosage of medications used by the subjects were computed in terms of chlorpromazine equivalent and entered into the analysis. Results: patients in contrast to controls (PConclusion: SNSs are primary signs in schizophrenia and are more prevalent among non-paranoid patients than patients with diagnosis of paranoid disorder. The SNSs seem not to be affected by medication and are significantly correlated with negative symptoms of schizophrenia than thought disorder form.