Abstract

Introduction: To evaluate blood glucose and body weight in patients treated with clozapine and conventional antipsychotics.

Method: Forty-three patients with schizophrenia (36 males and 7 females) on clozapine were com- pared with 41 patients (33 males and 8 females) treated with conventional antipsychotics, regard-ing their fasting blood glucose (FBS), 2 hours post-prandial glucose (2HPPG) and body mass index (BMI). Data were analyzed using t-test and the chi-sqaure.

Results: Of the patients on clozapine, 2 had high FBS, 6 had high 2HPPG, and 5 were diagnosed with diabetes, which was significantly different from the group on conventional antipsychotics. More- over, comparing the BMIs, the patients on clozapine had higher weights than the conventional treatment group.

Conclusion: Clozapine may play a role in high blood glucose of some of the patients.