Objectives:  This study was carried out with the aim of  evaluating the attitude of adolescent students in the city of Tabriz toward drugs of abuse, high risk behaviors, and people with whom they interact. Method: In a descriptive cross-sectional study 500 secondary school students from the city of Tabriz which were selected using random multi-stage cluster sampling, were evaluated using demographic and attitude questionnaires. Data were analyzed using one-way analysis of variance and Pearson correlation test. Results: 92% of students denied the abuse of drugs, and 10% believed that drugs had a positive effect on people’s mood. 27% believed that curiosity is a factor that causes the attraction to drugs. 4% of students reported  going to places with a high risk considering drugs of abuse. Students discussed drugs more with their friends, family, and teachers in order 9% do not introduce their friends to their parents. Pearson correlation coefficient test showed significant and positive correlation between age (p<0.004), number of family members (p<0.05), and birth order (p<0.05) with total attitude score and pro-social behaviors. But the correlation between pro-social behaviors and students average score was not significant statistically. Conclusion: The design and application of interactions based on prevention from peers with the cooperation of parents, is necessary in the school and in the family.