Volume 14, Issue 2 (8-2008)                   IJPCP 2008, 14(2): 131-139 | Back to browse issues page

XML Persian Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Fayazi Bordbar M R, Abdollahian E, Hojjat K, Samaric A A. Effects of Selegiline on Negative Symptoms in Schizophrenia: A Double-Blind Clinical Trial . IJPCP. 2008; 14 (2) :131-139
URL: http://ijpcp.iums.ac.ir/article-1-462-en.html
1- , E-mail: fayyazimr@mums.ac.ir
Abstract:   (13554 Views)


Objectives: This research was carried out with the aim of examining the effects of selegiline, a monoamine oxidase-B inhibitor with dopaminergic features, on the treatment of patients with schizophrenia with prominent negative symptoms.

Method: In a clinical trial, 80 inpatients at the Hejazi Hospital in Meshed, who were diagnosed with schizophrenia based on Diagnostic and Statistical Manual of Mental Disorders-fourth edition-Text Revision (DSM-IV-TR) criteria, and had prominent negative symptoms (a score of over 15 in Positive and Negative Symptom Scale [PANSS]) entered the study. The patients were randomly divided into three groups: Patients receiving 5mg selegiline, patients receiving 10mg selegiline, and those receiving placebo along with an antipsychotic drug. The patients were then followed-up for six weeks using PANSS and Drug Side Effects Test. Data were analyzed using analysis of variance and t-test.

Results: Eight patients were excluded from the study due to an increase in psychotic symptoms and four were excluded because of drug side effects. Mean age of patients was 47.6 and the mean duration of hospitalization was 8.9 years. Even though there was an improvement in negative symptoms in both groups receiving selegiline, the difference between the groups receiving selegiline and the group receiving placebo was not significant.

Conclusion: Selegiline is not superior to placebo in reducing negative symptoms in hospitalized patients.


Full-Text [PDF 228 kb]   (3123 Downloads)    
Type of Study: Original Research | Subject: Psychiatry and Psychology
Received: 2008/08/30

Add your comments about this article : Your username or Email:

Send email to the article author

© 2019 All Rights Reserved | Iranian Journal of Psychiatry and Clinical Psychology

Designed & Developed by : Yektaweb