Objectives: The goal of the present study was to describe the experience of female psychiatric inpatients, of couple-family relationships. Method: The method of phenomenology was used in this qualitative study. The subjects comprised female patients hospitalized in Noor Psychiatric Hospital in Isfahan. Fourteen subjects were selected using purpose-oriented sampling, up to reaching data saturation. Data were collected using an unstructured interview and Colaizzi’s seven stage process was used for data analysis.  Results: The findings were classified in 847 conceptual codes. Subsequent to the fourth level coding,  the data were divided into two main groups: (1) causes of the illness and their aggravating factors (behavior of spouse, behavior of spouse’s family, behavior of subject, miscellaneous factors and childhood and adolescence period), and (2) subjects’ reactions (to the behavior of spouse, toward continuing to live and to sexual relation with spouse). Conclusion: Women experience many negative events in their marital life, with undesired effects on mental health. Taking these issues into consideration and providing families and couples with related education could have significant effects in improving mental health among women.