Volume 12, Number 4 (2-2007)                   IJPCP 2007, 12(4): 359-364 | Back to browse issues page

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Mazhari S, Haghshenas H, Firooz-abadi A. Verbal Memory, Visual Memory and Working Memory in Patients with Schizophrenia and their First-degree Relatives . IJPCP. 2007; 12 (4) :359-364
URL: http://ijpcp.iums.ac.ir/article-1-124-en.html

Abstract:   (9483 Views)


Objectives: Assessment of cognitive deficits in patients with schizo-phrenia bears significant implications, particulary in localizing the underlying accompanying neurological impairments. This study aimed for evaluation of cognitive deficits in first-degree relatives of these patients who reflect the same underlying genetic vulnerability for the disorder.

Method: In this cross-sectional study, 30 patients with schizophrenia, 30 first-degree relatives, and 30 control subjects were assessed. They completed tests of verbal & visual paired associate recall, Wechsler digit span, and Paced Auditory Serial Addition Test (PASAT). Data were analysed using statistical t-test, ANOVA, Tukey test, Chi-square, and Kruskal-Wallis test.

Results: Our study revealed alterations in the memory of patients with schizophrenia and their first-degree relatives compared to the controls. Both patients and their relatives also showed significant diffrence in verbal and visual paired associate recall tests, backward digit span, and PASAT.

Conclusion: Diminished cognitive functions is observed in first-degree relatives of patients with schizophrenia. Verbal and visual paired asso-ciation tests, Backward digit Span test, and PASAT may indicate vulner-ability towards this disorder.


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Type of Study: Original Research |
Received: 2007/05/21

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