fa مقایسه اثربخشی بوسپیرون و متیل‌فنیدیت در کودکان مبتلا به اختلال بیش‌فعالی کم‌توجهی روانپزشکی و روانشناسی Psychiatry and Psychology پژوهشي اصيل Original Research <p class="a" dir="rtl" style="MARGIN: 0cm 0cm 0pt LINE-HEIGHT: 12.5pt mso-line-height-rule: exactly"><strong><u><span lang="AR-SA" style="FONT-SIZE: 8pt FONT-STYLE: normal FONT-FAMILY: Tahoma">هدف</span></u><span lang="AR-SA" style="FONT-SIZE: 8pt FONT-STYLE: normal FONT-FAMILY: Tahoma">:</span></strong><span lang="AR-SA" style="FONT-WEIGHT: normal FONT-SIZE: 8pt FONT-STYLE: normal FONT-FAMILY: Tahoma"> بررسی اثربخشی و عوارض جانبی بوسپیرون در مقایسه با متیل‌فنیدیت در کنترل نشانه‌های کودکان مبتلا به اختلال بیش‌فعالی کم‌‌توجهی </span><span dir="ltr"></span><span dir="ltr" style="FONT-WEIGHT: normal FONT-SIZE: 8pt FONT-STYLE: normal FONT-FAMILY: Tahoma"><span dir="ltr"></span>(ADHD)</span><span dir="rtl"></span><span lang="AR-SA" style="FONT-WEIGHT: normal FONT-SIZE: 8pt FONT-STYLE: normal FONT-FAMILY: Tahoma"><span dir="rtl"></span>. </span><strong><u><span lang="AR-SA" style="FONT-SIZE: 8pt FONT-STYLE: normal FONT-FAMILY: Tahoma">روش</span></u><span lang="AR-SA" style="FONT-SIZE: 8pt FONT-STYLE: normal FONT-FAMILY: Tahoma">:</span></strong><span lang="AR-SA" style="FONT-WEIGHT: normal FONT-SIZE: 8pt FONT-STYLE: normal FONT-FAMILY: Tahoma"> 32 کودک 12- 6 ساله مبتلا به </span><span dir="ltr" style="FONT-WEIGHT: normal FONT-SIZE: 8pt FONT-STYLE: normal FONT-FAMILY: Tahoma">ADHD</span><span dir="rtl"></span><span lang="AR-SA" style="FONT-WEIGHT: normal FONT-SIZE: 8pt FONT-STYLE: normal FONT-FAMILY: Tahoma"><span dir="rtl"></span> مورد بررسی قرار گرفتند. برای گردآوری داده‌ها مقیاس ارزیابی </span><span dir="ltr" style="FONT-WEIGHT: normal FONT-SIZE: 8pt FONT-STYLE: normal FONT-FAMILY: Tahoma">ADHD</span><span dir="rtl"></span><span style="FONT-WEIGHT: normal FONT-SIZE: 8pt FONT-STYLE: normal FONT-FAMILY: Tahoma"><span dir="rtl"></span> </span><span dir="ltr"></span><span dir="ltr" style="FONT-WEIGHT: normal FONT-SIZE: 8pt FONT-STYLE: normal FONT-FAMILY: Tahoma"><span dir="ltr"></span>(ADHD-RS)</span><span dir="rtl"></span><span style="FONT-WEIGHT: normal FONT-SIZE: 8pt FONT-STYLE: normal FONT-FAMILY: Tahoma"><span dir="rtl"></span> <span lang="AR-SA"><font size="2">فرم پدر و مادر و آموزگار برای هر دو گروه به‌کار برده شد. عوارض دارویی بر پایه فهرست عوارض جانبی این دو دارو بررسی شد. دوز دارو برای بیماران در گروه بوسپیرون </font></span></span><span dir="ltr" style="FONT-WEIGHT: normal FONT-SIZE: 8pt FONT-STYLE: normal FONT-FAMILY: Tahoma">mg/kg/day</span><span dir="rtl"></span><span lang="AR-SA" style="FONT-WEIGHT: normal FONT-SIZE: 8pt FONT-STYLE: normal FONT-FAMILY: Tahoma"><span dir="rtl"></span> 5/0 و در گروه متیل فنیدیت </span><span dir="ltr" style="FONT-WEIGHT: normal FONT-SIZE: 8pt FONT-STYLE: normal FONT-FAMILY: Tahoma">mg/kg/day</span><span dir="rtl"></span><span style="FONT-WEIGHT: normal FONT-SIZE: 8pt FONT-STYLE: normal FONT-FAMILY: Tahoma"><span dir="rtl"></span> <span lang="AR-SA"><font size="2">1- 3/0 بود. داده‌ها به‌کمک آزمون‌های آماری </font></span></span><span dir="ltr" style="FONT-WEIGHT: normal FONT-SIZE: 8pt FONT-STYLE: normal FONT-FAMILY: Tahoma">t</span><span dir="rtl"></span><span style="FONT-WEIGHT: normal FONT-SIZE: 8pt FONT-STYLE: normal FONT-FAMILY: Tahoma mso-bidi-language: FA"><span dir="rtl"></span> <span lang="FA"><font size="2">جفت‌شده، تحلیل واریانس یک‌راهه با اندازه‌گیر‌ی‌های مکرر، آزمون </font></span></span><span dir="ltr" style="FONT-WEIGHT: normal FONT-SIZE: 8pt FONT-STYLE: normal FONT-FAMILY: Tahoma mso-bidi-language: FA">t</span><span dir="rtl"></span><span lang="FA" style="FONT-WEIGHT: normal FONT-SIZE: 8pt FONT-STYLE: normal FONT-FAMILY: Tahoma mso-bidi-language: FA"><span dir="rtl"></span> مستقل و آزمون خی‌دو تحلیل شدند.</span><span lang="FA" style="FONT-WEIGHT: normal FONT-SIZE: 8pt FONT-STYLE: normal FONT-FAMILY: Tahoma"> </span><strong><u><span lang="AR-SA" style="FONT-SIZE: 8pt FONT-STYLE: normal FONT-FAMILY: Tahoma">یافته‌ها</span></u><span lang="AR-SA" style="FONT-SIZE: 8pt FONT-STYLE: normal FONT-FAMILY: Tahoma">:</span><span dir="ltr"></span></strong><span lang="AR-SA" dir="ltr" style="FONT-WEIGHT: normal FONT-SIZE: 8pt FONT-STYLE: normal FONT-FAMILY: Tahoma"><span dir="ltr"></span> </span><span lang="AR-SA" style="FONT-WEIGHT: normal FONT-SIZE: 8pt FONT-STYLE: normal FONT-FAMILY: Tahoma">در پایان شش هفته، هر دو گروه نسبت به پیش از آغاز بررسی، در نمره کلی </span><span dir="ltr" style="FONT-WEIGHT: normal FONT-SIZE: 8pt FONT-STYLE: normal FONT-FAMILY: Tahoma">ADHD-RS</span><span dir="rtl"></span><span lang="AR-SA" style="FONT-WEIGHT: normal FONT-SIZE: 8pt FONT-STYLE: normal FONT-FAMILY: Tahoma"><span dir="rtl"></span> و زیرمقیاس‌های بی‌توجهی، بیش‌فعالی و تکانش‌گری کاهش </span><span lang="FA" style="FONT-WEIGHT: normal FONT-SIZE: 8pt FONT-STYLE: normal FONT-FAMILY: Tahoma mso-bidi-language: FA">معنی‌دار </span><span lang="AR-SA" style="FONT-WEIGHT: normal FONT-SIZE: 8pt FONT-STYLE: normal FONT-FAMILY: Tahoma">(001/0=</span><span dir="ltr" style="FONT-WEIGHT: normal FONT-SIZE: 8pt FONT-STYLE: normal FONT-FAMILY: Tahoma">p</span><span dir="rtl"></span><span lang="FA" style="FONT-WEIGHT: normal FONT-SIZE: 8pt FONT-STYLE: normal FONT-FAMILY: Tahoma mso-bidi-language: FA"><span dir="rtl"></span>) </span><span lang="AR-SA" style="FONT-WEIGHT: normal FONT-SIZE: 8pt FONT-STYLE: normal FONT-FAMILY: Tahoma">نشان دادند، ولی مقایسه دوگروه در نمره کلی </span><span dir="ltr" style="FONT-WEIGHT: normal FONT-SIZE: 8pt FONT-STYLE: normal FONT-FAMILY: Tahoma">ADHD-RS</span><span dir="rtl"></span><span style="FONT-WEIGHT: normal FONT-SIZE: 8pt FONT-STYLE: normal FONT-FAMILY: Tahoma"><span dir="rtl"></span> <span lang="AR-SA"><font size="2">پدر و مادر (77/0=</font></span></span><span dir="ltr" style="FONT-WEIGHT: normal FONT-SIZE: 8pt FONT-STYLE: normal FONT-FAMILY: Tahoma">p</span><span dir="rtl"></span><span lang="AR-SA" style="FONT-WEIGHT: normal FONT-SIZE: 8pt FONT-STYLE: normal FONT-FAMILY: Tahoma"><span dir="rtl"></span>) و آموزگار (23/0=</span><span dir="ltr" style="FONT-WEIGHT: normal FONT-SIZE: 8pt FONT-STYLE: normal FONT-FAMILY: Tahoma">p</span><span dir="rtl"></span><span lang="FA" style="FONT-WEIGHT: normal FONT-SIZE: 8pt FONT-STYLE: normal FONT-FAMILY: Tahoma mso-bidi-language: FA"><span dir="rtl"></span>) </span><span lang="AR-SA" style="FONT-WEIGHT: normal FONT-SIZE: 8pt FONT-STYLE: normal FONT-FAMILY: Tahoma">تفاوتی نشان نداد. دو گروه در زیرمقیاس بی‌توجهی تفاوت داشتند، به‌طوری که متیل فنیدیت بر بوسپیرون برتری داشت. عوارض جانبی بوسپیرون کمتر از متیل‌فنیدیت بود. </span><strong><u><span lang="AR-SA" style="FONT-SIZE: 8pt FONT-STYLE: normal FONT-FAMILY: Tahoma">نتیجه‌گیری</span></u><span lang="AR-SA" style="FONT-SIZE: 8pt FONT-STYLE: normal FONT-FAMILY: Tahoma">:</span></strong><span lang="AR-SA" style="FONT-WEIGHT: normal FONT-SIZE: 8pt FONT-STYLE: normal FONT-FAMILY: Tahoma"> بوسپیرون نیمرخ عوارض جانبی مطلوبی دارد و باعث بهبود محسوس در علایم </span><span dir="ltr" style="FONT-WEIGHT: normal FONT-SIZE: 8pt FONT-STYLE: normal FONT-FAMILY: Tahoma">ADHD</span><span dir="rtl"></span><span style="FONT-WEIGHT: normal FONT-SIZE: 8pt FONT-STYLE: normal FONT-FAMILY: Tahoma"><span dir="rtl"></span> <span lang="AR-SA"><font size="2">می‌شود</font></span></span><span dir="ltr"></span><span dir="ltr" style="FONT-WEIGHT: normal FONT-SIZE: 8pt FONT-STYLE: normal FONT-FAMILY: Tahoma"><span dir="ltr"></span>.</span><span dir="rtl"></span><span lang="AR-SA" style="FONT-WEIGHT: normal FONT-SIZE: 8pt FONT-STYLE: normal FONT-FAMILY: Tahoma"><span dir="rtl"></span> این یافته‌های اولیه در مورد اثربخشی بوسپیرون در کودکان مبتلا به </span><span dir="ltr" style="FONT-WEIGHT: normal FONT-SIZE: 8pt FONT-STYLE: normal FONT-FAMILY: Tahoma">ADHD</span><span dir="rtl"></span><span lang="AR-SA" style="FONT-WEIGHT: normal FONT-SIZE: 8pt FONT-STYLE: normal FONT-FAMILY: Tahoma"><span dir="rtl"></span> به بررسی‌های بیشتری نیاز دارد. </span><i><b><span lang="AR-SA" style="FONT-SIZE: 9.5pt FONT-FAMILY: "> </span></b></i></p> <p class="MsoNormal" style="TEXT-JUSTIFY: kashida MARGIN: 0cm 0cm 0pt DIRECTION: ltr LINE-HEIGHT: 11pt unicode-bidi: embed TEXT-ALIGN: justify TEXT-KASHIDA: 0% mso-line-height-rule: exactly"><b><span style="FONT-SIZE: 10pt mso-bidi-font-family: 'Times New Roman'"><font face="Times New Roman">Abstract</font></span></b><p></p><p class="MsoNormal" style="TEXT-JUSTIFY: kashida MARGIN: 0cm 0cm 0pt DIRECTION: ltr LINE-HEIGHT: 11pt unicode-bidi: embed TEXT-ALIGN: justify TEXT-KASHIDA: 0% mso-line-height-rule: exactly"><font face="Times New Roman"><b><u><span style="FONT-SIZE: 9pt mso-bidi-font-family: 'Times New Roman'">Objectives</span></u></b><b><span style="FONT-SIZE: 9pt mso-bidi-font-family: 'Times New Roman'">:</span></b><span style="FONT-SIZE: 9pt mso-bidi-font-family: 'Times New Roman'"> To investigate the efficacy and side effects of buspirone in comparison with methylphenidate for controlling symptoms of children with attention deficit hyperactivity disorder (ADHD). <b><u>Method</u>:</b> A total of thirty two 6-12 years old children with ADHD were examined. The teacher and parent ADHD Rating Scale (ADHD-RS) was used to gather data from both groups. Drug side effects were assessed based on side effect checklists for both drugs. Dosage of drug for patients was 0.5 mg/kg/day for the buspirone group and 0.3-1 mg/kg/day for the methylphenidate group. Data were analysed using paired t test, one way analysis of variance with repeated measures, independent t test and </span></font><span style="FONT-SIZE: 9pt FONT-FAMILY: Symbol mso-bidi-font-family: 'Times New Roman' mso-ascii-font-family: 'Times New Roman' mso-hansi-font-family: 'Times New Roman' mso-char-type: symbol mso-symbol-font-family: Symbol"><span style="mso-char-type: symbol mso-symbol-font-family: Symbol"><font face="Symbol">c</font></span></span><font face="Times New Roman">^{<span style="FONT-SIZE: 9pt mso-bidi-font-family: 'Times New Roman'">2</span>}<span style="FONT-SIZE: 9pt mso-bidi-font-family: 'Times New Roman'">. <b><u>Results</u>:</b> In the end of six weeks, both groups showed decreases in the total score of ADHD-RS in subscales of attention deficit, hyper-activity, and impulsivity (p<0.001). No significant differences were observed between the two groups on the parent (p=0.77) and teacher (p=0.23) rating scale scores. The groups were different regarding the inattention subscale, with methylphenidate being superior to buspirone. Side effects of buspirone were mild and rare in comparison with that of methylphenidate. <b><u>Conclusion</u>:</b> Buspirone has a favorable side effect profile and it improves ADHD symptoms significantly. These preliminary findings of efficacy of buspirone in children with ADHD need further studies.</span></font><p></p></p><p></p></p><p></p> اختلال بیش‌فعالی با کمبود توجه؛ بوسپیرون؛ متیل‌فنیدیت children adhd; Buspirone; methylphenidate 223 230 http://ijpcp.iums.ac.ir/browse.php?a_code=A-10-1-361&slc_lang=fa&sid=1 Mahin Eslamishahr Babaki مهین اسلامی شهربابکی 180031947532846003491 180031947532846003491 No Rosita Davari Ashtiani رزیتا داوری آشتیانی E-mail: rodavari@yahoo.com 180031947532846003492 180031947532846003492 Yes Katayoon Razjooyan کتایون رازجویان 180031947532846003493 180031947532846003493 No Homayoon Amini همایون امینی 180031947532846003494 180031947532846003494 No