Iranian Journal of Psychiatry and Clinical Psychology

fa اثر افزودن نالترکسون در درمان اسکیزوفرنیا: مقایسه دو سوکور با دارونما Naltrexone as an Adjunct to Treatment of Schizophrenia: A Double Blind Placebo Controlled Trial روانپزشکی و روانشناسی Psychiatry and Psychology پژوهشي اصيل Original Research AbstractIntroduction: Given the role of opioids and their antagonists on dopamine secretion, the effect of naltrexone use in the treatment of schizophrenia was evaluated in this study. Method: In a double blind placebo controlled clinical trial study on a group of 34 patients with schizophrenia on maintenance therapy with antipsychotics, 17 patients received naltrexone (50 mg, BID) and 17 patients received placebo (BID). The patients were evaluated at the start of the trial, as well as three and six weeks after, using Positive and Negative Syndrome Scale (PANSS).Results: Patients receiving naltrexone showed improvement in positive symptoms from week three to week six, and improvement in negative symptoms from week one to week three.Conclusion: Naltrexone had no significant effect on positive or negative symptoms of schizo-phrenia compared to placebo. کلیدواژه: اسکیزوفرنیا، نالترکسون، اپیویید، علایم منفی، علایم مثبت، درمان نگهدارنده Key words: schizophrenia, naltrexone, opioid, positive symptoms, negative symptoms, maintenance therapy 49 54 http://ijpcp.iums.ac.ir/browse.php?a_code=A-10-1-36&slc_lang=fa&sid=1 Sh. S. Goodarzi شاهرخ سردارپور گودرزی 18003194753284600156 18003194753284600156 No M. Arbabi محمد اربابی E-mial: arbabi_m@sina.tums.ac.ir 18003194753284600157 18003194753284600157 Yes M. Samimi Ardestani مهدی صمیمی اردستانی 18003194753284600158 18003194753284600158 No