Iranian Journal of Psychiatry and Clinical Psychology

fa مقایسه مصرف آنتی‌سایکوتیک‌های تیپیک و آتیپیک در ایجاد علایم وسواسی بیماران مبتلا به اسکیزوفرنیا A Comparison of the Effects of Typical and Atypical Antipsychotics on Inducing Obsessive-Compulsive Symptoms in Patients with Schizophrenia روانپزشکی و روانشناسی Psychiatry and Psychology پژوهشي اصيل Original Research <p class="MsoNormal" style="TEXT-JUSTIFY: kashida MARGIN: 0cm 6.5pt 0pt 0cm DIRECTION: ltr TEXT-INDENT: 0cm LINE-HEIGHT: 12pt unicode-bidi: embed TEXT-ALIGN: justify TEXT-KASHIDA: 0% mso-line-height-rule: exactly">Abstract<p class="MsoNormal" style="TEXT-JUSTIFY: kashida MARGIN: 0cm 6.5pt 0pt 0cm DIRECTION: ltr TEXT-INDENT: 0cm LINE-HEIGHT: 12pt unicode-bidi: embed TEXT-ALIGN: justify TEXT-KASHIDA: 0% mso-line-height-rule: exactly">Objectives: The effects of typical and atypical antipsychotics on inducing obsessive-compulsive symptoms in patients with schizophrenia were compared in this study. <p class="MsoNormal" style="TEXT-JUSTIFY: kashida MARGIN: 0cm 6.5pt 0pt 0cm DIRECTION: ltr TEXT-INDENT: 0cm LINE-HEIGHT: 12pt unicode-bidi: embed TEXT-ALIGN: justify TEXT-KASHIDA: 0% mso-line-height-rule: exactly">Method: In a comparative-descriptive study 64 patients with schizophrenia (32 patients in typical antipsychotic group and 32 patients in atypical antipsychotic group) were investigated. All patients with a confirmed diagnosis of schizophrenia based on Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I), underwent Yale-Brown Obsessive Compulsive Scale (Y-BOCS) and Brief Psychiatric Rating Scale (BPRS) at the beginning, as well as three and six weeks after treatment. Data were analyzed using descriptive statistics, repeated measures analysis of variance, and t-test. <p class="MsoNormal" style="TEXT-JUSTIFY: kashida MARGIN: 0cm 6.5pt 0pt 0cm DIRECTION: ltr TEXT-INDENT: 0cm LINE-HEIGHT: 12pt unicode-bidi: embed TEXT-ALIGN: justify TEXT-KASHIDA: 0% mso-line-height-rule: exactly">Results: In the group receiving typical antipsychotics, mean Y-BOCS scores were 2.40, 2.30, and 2.18 at the beginning, at three weeks and at six weeks after treatment respectively. Also, in the group receiving atypical antipsychotics Y-BOCS scores were 4.12, 4.46, and 4.53 at the beginning, at three weeks and at six weeks after treatment respectively. The difference of Y-BOCS scores in the two groups receiving typical and atypical antipsychotics was close to significance before treatment, and significant at three and six weeks after treatment (p<0.05). In the typical group one patient with positive family history showed a decrease in obsessive-compulsive symptoms, and in the atypical group one patient with positive family history showed an increase in obsessive-compulsive symptoms. <p class="MsoNormal" style="TEXT-JUSTIFY: kashida MARGIN: 0cm 6.5pt 0pt 0cm DIRECTION: ltr TEXT-INDENT: 0cm LINE-HEIGHT: 12pt unicode-bidi: embed TEXT-ALIGN: justify TEXT-KASHIDA: 0% mso-line-height-rule: exactly">Conclusion: Atypical antipsychotics can induce obsessive-compulsive symptoms in patients with schizophrenia. Despite the importance of family history in the clinical manifestations of obsession in atypical antipsychotic users, the role of this factor in the increase or decrease in obsessive-compulsive symptoms was minimal. آنتی‌سایکوتیک‌های تیپیک، آنتی‌سایکوتیک‌های آتیپیک، علایم وسواسی، اسکیزوفرنیا typical antipsychotics, atypical antipsychotics, obsessive-compulsive symptoms, schizophrenia 328 334 http://ijpcp.iums.ac.ir/browse.php?a_code=A-10-1-263&slc_lang=fa&sid=1 Shima Mohseni شیما محسنی 180031947532846001395 180031947532846001395 No Azizeh Afkham Ebrahimi عزیزه افخم ابراهیمی E-mail: afkhami@iums.ac.ir 180031947532846001396 180031947532846001396 Yes Badry Daneshamouz بدری دانش‌آموز 180031947532846001397 180031947532846001397 No