Iranian Journal of Psychiatry and Clinical Psychology

fa مقایسه کارایی ترکیب فلوکستین- هالوپریدول با فلوکستین - دارونما در بیماران اختلال وسواسی- جبری Comparison of Efficacy of Fluoxetine-Haloperidol vs. Fluoxetine-Placebo in Obsessive-Compulsive Patients روانپزشکی و روانشناسی Psychiatry and Psychology پژوهشي اصيل Original Research Abstract Objectives: This study was designed to investigate the possibility of dopaminergic involve-ment in obsessive-compulsive patients (OCD). Method: This double-blind study compared the efficacy of fluoxetine-haloperidol with that of fluoxetine-placebo in two groups, each comprised of 12 subjects. These subjects with obsessive-compulsive disorders were selected on the basis of DSM-IV diagnostic criteria they were asse- ssed by a demographic questionnaire and Yale-Brown Scale for evaluating obsessive-compul- sive disorders. Findings: The results showed that the response to treatment in haloperidol-fluoxetine group was somewhat better than the fluoxetine-placebo group from the first week of the study. The difference was significant at the third visit (end of fourth week). Results: In addition to serotonin neurotransmitter system, dopaminergic system may play a role in pathophysiology of obsessive-compulsive disorder. وسواسی- اجباری، فلوکستین، هالوپریدول obsessive-compulsive disorder, fluoxetine, haloperidol 4 10 http://ijpcp.iums.ac.ir/browse.php?a_code=A-10-1-202&slc_lang=fa&sid=1 Gh.R. Mirsepasi غلامرضا میرسپاسی 18003194753284600768 18003194753284600768 No A. Saliani انوشه سالیانی E-mail: drsaliani@mail.com 18003194753284600769 18003194753284600769 Yes