fa نرم‌نشانه‌های عصبی در بیماران دچار نخستین دوره سایکوز، بستگان درجه اول آنها و افراد سالم روانپزشکی و روانشناسی Psychiatry and Psychology پژوهشي اصيل Original Research <p>  </p><p> <strong> Abstract </strong></p><p> <strong> Objectives: </strong>This study aimed to evaluate and compare neurological soft signs (NSS) in patients with first episode psychosis, in their first-degree relatives, and in healthy control subjects. </p><p> <strong> Method: </strong>Thirty patients with first-episode psychosis, 30 of their first-degree relatives, and 30 healthy controls were evaluated by the Structured Clinical Interview for DSM-IV (SCID) for psychiatric assessment. Neurological Evaluation Scale (NES) was used for the evaluation of NSS, and Edinburgh Handedness Inventory (EHI) for laterality assessment. Data were analyzed by the following statistical tests: Chi-square, t-test, Fisher’s Exact Test, Kolmogorov-Smirnov Test, and non-parametric tests of Kruskal-Wallis and Mann-Whitney. </p><p> <strong> Results: </strong>First-episode psychotic patients had significantly higher NES total scores than the first-degree relatives, and the control group. On “sequencing of complex motor acts”, “motor coordination”, and “sensory integration” subscales of the NES, patients had significantly higher scores than the controls (respective p-values of <0.01, <0.001, & <0.01). Patients had significantly higher scores than their relatives on “motor coordination”, and “eye movements” (p-values <0.05). There were no significant differences in NSS between the first-degree relatives and healthy controls on NES total scores. </p><p> <strong> Conclusion: </strong>A higher prevalence of NSS occurs in patients with first-episode psychosis than in their relatives or healthy control subjects. Neurological soft signs are part of a neural dysfunction that underlies psychosis rather than the consequence of a neurodegene-rative processes caused by the disease. </p> سایکوز بار اول، نرم‌نشانه‌های عصبی، اسکیزوفرنیا first-episode psychosis, neurological soft sings, schizophrenia 89 96 http://ijpcp.iums.ac.ir/browse.php?a_code=A-10-1-157&slc_lang=fa&sid=1 Homayoun Amini همایون امینی E-mail: aminihom@sina.tums.ac.ir 18003194753284600577 18003194753284600577 Yes Fatemeh Rahimi- Nejad فاطمه رحیمی‌نژاد 18003194753284600578 18003194753284600578 No Tehran University of Medical Sciences دانشگاه علوم پزشکی تهران Maryam Noroozian مریم نوروزیان 18003194753284600579 18003194753284600579 No Vandad Sharifi ونداد شریفی 18003194753284600580 18003194753284600580 No Majid Shakiba مجید شکیبا 18003194753284600581 18003194753284600581 No