Iranian Journal of Psychiatry and Clinical Psychology

fa حافظه کلامی، دیداری و در جریان در بیماران مبتلا به ‌اسکیزوفرنیا و بستگان درجه‌ اول Verbal Memory, Visual Memory and Working Memory in Patients with Schizophrenia and their First-degree Relatives پژوهشي اصيل Original Research <p class="MsoNormal" style="TEXT-JUSTIFY: kashida DIRECTION: ltr TEXT-INDENT: 0cm LINE-HEIGHT: 14pt MARGIN-RIGHT: 6.5pt unicode-bidi: embed TEXT-ALIGN: justify TEXT-KASHIDA: 0% mso-line-height-rule: exactly">Abstract<p class="MsoNormal" style="TEXT-JUSTIFY: kashida DIRECTION: ltr TEXT-INDENT: 0cm LINE-HEIGHT: 14pt unicode-bidi: embed TEXT-ALIGN: justify TEXT-KASHIDA: 0% mso-line-height-rule: exactly mso-layout-grid-align: none">Objectives: Assessment of cognitive deficits in patients with schizo-phrenia bears significant implications, particulary in localizing the underlying accompanying neurological impairments. This study aimed for evaluation of cognitive deficits in first-degree relatives of these patients who reflect the same underlying genetic vulnerability for the disorder. <p class="MsoNormal" style="TEXT-JUSTIFY: kashida DIRECTION: ltr TEXT-INDENT: 0cm LINE-HEIGHT: 14pt unicode-bidi: embed TEXT-ALIGN: justify TEXT-KASHIDA: 0% mso-line-height-rule: exactly mso-layout-grid-align: none">Method: In this cross-sectional study, 30 patients with schizophrenia, 30 first-degree relatives, and 30 control subjects were assessed. They completed tests of verbal & visual paired associate recall, Wechsler digit span, and Paced Auditory Serial Addition Test (PASAT). Data were analysed using statistical t-test, ANOVA, Tukey test, Chi-square, and Kruskal-Wallis test. <p class="MsoNormal" style="TEXT-JUSTIFY: kashida DIRECTION: ltr TEXT-INDENT: 0cm LINE-HEIGHT: 14pt unicode-bidi: embed TEXT-ALIGN: justify TEXT-KASHIDA: 0% mso-line-height-rule: exactly mso-layout-grid-align: none">Results: Our study revealed alterations in the memory of patients with schizophrenia and their first-degree relatives compared to the controls. Both patients and their relatives also showed significant diffrence in verbal and visual paired associate recall tests, backward digit span, and PASAT. <p class="MsoNormal" style="TEXT-JUSTIFY: kashida DIRECTION: ltr TEXT-INDENT: 0cm LINE-HEIGHT: 14pt unicode-bidi: embed TEXT-ALIGN: justify TEXT-KASHIDA: 0% mso-line-height-rule: exactly mso-layout-grid-align: none">Conclusion: Diminished cognitive functions is observed in first-degree relatives of patients with schizophrenia. Verbal and visual paired asso-ciation tests, Backward digit Span test, and PASAT may indicate vulner-ability towards this disorder.<p class="MsoNormal" style="TEXT-JUSTIFY: kashida DIRECTION: ltr TEXT-INDENT: 0cm LINE-HEIGHT: 14pt MARGIN-RIGHT: 6.5pt unicode-bidi: embed TEXT-ALIGN: justify TEXT-KASHIDA: 0% mso-line-height-rule: exactly"> کلیدواژه: اسکیزوفرنیا، بستگان درجه‌ اول، حافظه کلامی‌، حافظه دیداری، حافظه در جریان Key words: Schizophrenia, first-degree relatives, verbal memory, visual memory, working memory 359 364 http://ijpcp.iums.ac.ir/browse.php?a_code=A-10-1-124&slc_lang=fa&sid=1 Shahrzad Mazhari شهرزاد مظهری 18003194753284600444 18003194753284600444 Yes Hasan Haghshenas حسن حق‌شناس 18003194753284600445 18003194753284600445 No Ali Firooz-abadi علی فیروزآبادی 18003194753284600446 18003194753284600446 No