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Abstract

Objectives: The efficacy of high doses of buprenorphine prescription in one day was compared with the usual method.

Method: In a double-blind trial, 40 patients with the diagnosis of opioid dependence (based on DSM- IV criteria) were randomly assigned into two groups. 20 patients received 12 mg of buprenorphine intramuscularly in divided doses during one day long 20 other patients were administered the usual decreasing doses of buprenorphine over five days. The followings were evaluated: success rate in detoxification, treatment retention in days, intensity of subjective withdrawal symptoms, intensity of objective withdrawal symptoms, level of drug craving, level of adjuvant drug use, drug side-effects, rate of positive urine tests for opioids, and levels of hepatic enzymes. Data were analyzed via statis- tical c², t, Mann-Whitney, and Fisher tests.

Findings: There was no significant difference between the two groups across most variables. The only difference observed was when the most withdrawal symptoms were evident, which was in the initial part of detoxification for the one-day treatment group and also at the end of the period for the five-days treatment group.

Results: To shorten the detoxification period, the one-day and high doses of buprenorphine treatment can be beneficial even though further evaluations with a larger sample may be required. However, the use of injectable buprenorphine is not recommended in routine clinical practice, because of its possible abuse and serious side effects.

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Objectives: Human body needs an adequate amount of night’s sleep after a long day to regain its power. This study aims to investigate the effectiveness of cognitive-behavioral therapy for insomnia (CBT-I) on emotional regulation and dysfunctional sleep beliefs among insomniac patients.
Methods: This was a quasi-experimental study with a pretest, post-test, follow-up test, and a control group. The sample included 43 people referring to sleep disorders clinics in Rasoul Akram Hospital and two private clinics for psychiatrists with a sleep fellowship in Tehran City, Iran in 2020. Of the 43 patients suffering from insomnia, according to the Diagnostic and Statistical Manual of Mental Disorders, 5th edition (DSM-5), 36 individuals were selected based on the inclusion and exclusion criteria, of which 20 cases were selected and randomly assigned to an experimental (n‌=‌10) and a control group (n‌=‌10). 
Results: The results demonstrated a significant difference between the emotional regulation and dysfunctional beliefs scores of the experimental and control groups in the post-test (P‌<‌0.05). The results of the follow-up test indicated the sustainable effects of the therapeutic intervention on emotional regulation and dysfunctional sleep beliefs of the experimental and control groups compared to the pretest (P‌<‌0.05).
Conclusion: Considering the significant effects of CBT-I on insomnia and dysfunctional sleep beliefs in the insomniac, this treatment can be used to improve their condition in sleep laboratories or other clinics.