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This research is based upon bio-psychological model in the assessment of the relative efficacy of different treatment procedures, namely behavioral models of tretment, drug treatment and a combination of these two for generalized anxiety disorders (GAD). In order to test the relative efficacy of each treatment the research study consisted of four groups: group I received training to control their anxiety by self- management techniques group II received only medication group III received a combination of the preceding two techniques group IV was treated as placebo group. Each group consisted of 5 subjects with an age range of 18-40 years. Tests pertaining to anxiety and depression, in addition to others, were given to the 20 subjects pre and post treatment. Results indicated that self control and pharmaceutical interventions were both effective in the reduction of anxiety level but not depression, combined treatment was more efficacious than self-control or drug therapy in the reduction of anxiety but has no significant effect on level of depression. Social adjustment increased in all three groups (namely, groups I, II, and III) with no significant differences noted among them. It is concluded that a combined method of intervention is more superior in the treatment of GAD than any one intervention alone.

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Objective: depression is one of the most common psychiatric disorders which may cause disability and premature mortality. Also coerces extra expenditures of depressed patients involved in the number of times referred to the physician, number of paraclinic checking , and the absent days from work or school throughout the year with those of the general population. Method: one hundred depressed patients (67% female and 33% male) and 100 non-depressed (66% female and 34% male) who had equal demographic status such as age, educational level and occupation, were assessed by questionnaire. The statistical data were analyzed through descriptive statistics and t-test. Findings: the findings indicate that the two groups were significantly different on the number of their referring to physicians (excluding psychiatric visits) and laboratory checkings also on the days not attending to their work or classes.

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Abstract Objectives: This study was designed to examine the prevalence of depression among primary school children in Mashhad. Method: For this study 2071 four and five grade (10-12 years old) children (1049 boys, 1022 girls) were selected through random cluster sampling from all the seven educational districts in Mashhad they were assessed in 1999–2000 using the Children Depression Inventory (CDI). The data were analyzed and further interpreted through application of non- parametric tests and statistical methods, Kolmogorov- Smirnov, Mann-Whitney, Wilcoxon and Kruskal-Walis, and linear correlation coefficients. Findings: The study demonstrated that the frequency of depression with a cut off point 20 in this city was 10.3% depression was more prevalent among girls than boys (girls 13.1%, boys 7.6%). Moreover, the following variables were shown to effect childhood depression: divorce, changing neighborhood, changing school, family’s socio-economic status, number of family members, traces of neuropsychiatric disorders in the family, and death of relatives. Results: The results indicate that children must be considered as a target group in future prevention plans. Moreover, utilizing screening tests to identify depression in children will help the health authorities to take secondary preventive measures more effectively.

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Abstract

Objectives: This research was carried out with the aim of examining the effects of selegiline, a monoamine oxidase-B inhibitor with dopaminergic features, on the treatment of patients with schizophrenia with prominent negative symptoms.

Method: In a clinical trial, 80 inpatients at the Hejazi Hospital in Meshed, who were diagnosed with schizophrenia based on Diagnostic and Statistical Manual of Mental Disorders-fourth edition-Text Revision (DSM-IV-TR) criteria, and had prominent negative symptoms (a score of over 15 in Positive and Negative Symptom Scale [PANSS]) entered the study. The patients were randomly divided into three groups: Patients receiving 5mg selegiline, patients receiving 10mg selegiline, and those receiving placebo along with an antipsychotic drug. The patients were then followed-up for six weeks using PANSS and Drug Side Effects Test. Data were analyzed using analysis of variance and t-test.

Results: Eight patients were excluded from the study due to an increase in psychotic symptoms and four were excluded because of drug side effects. Mean age of patients was 47.6 and the mean duration of hospitalization was 8.9 years. Even though there was an improvement in negative symptoms in both groups receiving selegiline, the difference between the groups receiving selegiline and the group receiving placebo was not significant.

Conclusion: Selegiline is not superior to placebo in reducing negative symptoms in hospitalized patients.