Dear Editor
Synthetic cannabinoids (SC) are a heterogeneous group of substances with a high affinity for cannabinoid receptors. Unlike Δ9-tetrahydrocannabinol (THC), synthetic cannabinoids are incredibly potent, highly productive, have more affinity for the cannabinoid receptor type 1 (CB1), and cannabinoid receptor type 2 (CB2), and are designed to accelerate the effects of tetrahydrocannabinol. Also, there is experimental evidence that SCs act on non-cannabinoid receptors, such as the 5-HT2B receptor or dopaminergic receptors [1, 2].
In 1984, following the attempts to treat multiple sclerosis (MS), John Hoffman developed a cannabis-like substance called K2, or chemical, which was a synthetic cannabinoid.
In Iran, Merasuite or Bonzai, accompanied by salvia, are used to produce the Chemical [2, 3].
In other countries, the chemical )in the language of the streets ‘Bonzai’( known as ‘1-naphthalene of methanol’ with its other name JWH-18 group, is a drug belonging to the group of synthetic cannabinoids, and its main psychoactive substance is Δ-9 tetra-hydro cannabinol (THC) with agonists effects on the CB1 and CB2 [2, 4 ,5, 6]. The sale of these drugs over the Internet and in special markets started from the beginning of 2004 with brands, such as Spice, K2, Black Mambo, Aroma, Dream, Bonzai, Maui Wowie, Nice Nice, etc. [1, 7].
Salvia (salvinorin A) is one of the most potent psychoactive substances and has a much stronger effect than its natural counterparts. Thus, it is much more harmful as well. These industrial samples bind to receptors in the brain, lungs, kidneys, and liver and affect the consumer’s body; thus, they have various psychological and physical effects. One of the most important effects is short-term memory impairment, severe hallucinations, dizziness, and visual disturbances [2, 8, 9, 10, 11]. Other manifestations are respiratory problems, high blood pressure, tachycardia, chest pain, muscle strain, acute renal failure, anxiety, irritability, psychosis, and also the idea of ​​suicide and cognitive impairment. Chronic use of synthetic cannabinoids has been associated with severe psychological and medical conditions and even death. The visual hallucinogenic effects of Salvia are very strong and similar to the effects of lysergic acid diethylamide (LSD). Some users have reported mystical and spiritual experiences [2, 12 ,13 ,14, 15]. 
Synthetic cannabinoids have become increasingly popular, especially among teenagers and young adults, despite their harms and hallucinogenic effects, and unfortunately are available at a low price. Although its consumption is increasing, most consumers are not familiar with the side effects; therefore, it seems necessary to introduce the physical and psychological effects to doctors, healthcare workers, families, and the general population, including teenagers. 

Ethical Considerations
Compliance with ethical guidelines
All ethical principles are considered in this article. 

Funding
This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

Authors contributions
Research, draft writing: Mohammad Faramarzi; editing and finalization of the text: Shiva Soraya; project management: All authors.

Conflicts of interest
The authors declare no conflicts of interest.

Acknowledgements
The Addiction Clinic of Iran Psychiatry Center, which helped us in completing this article, is thanked and appreciated.




References