Abstract

 Objectives:This research compared the efficacy of Phenobarbital and Amitriptyline in prevention of children migraine headache.

 Method: 28 children in two groups of 14 afflicted with migraine headache were matched by age, gender,and type of migraine.Treatment with the two medications ran for two months.To collect data, in addition to clinical interviews by a specialist in neurology,a daily form was used to register the frequency and intensity of the attacks. Analysis of data was implemented by t-test.

  Findings: Improvement was noted in 28.6% and 42.9% of children who took respectively Phenobar- bital and Amitriptyline.The difference between the two groups was not statistically significant.Fur- thermore, the children taking Amitriptyline exhibited more side effects than the other group.

 Results:This evaluation revealed that both spoken medicines were effective in prevention of mig- raine attackshowever,considering Phenobarbital’s lesser side effects,its prescription seems super-ior in prevention of children migraine.