This paper reports five cases of Neuroleptic Malignant Syndrome, admitted to Shahid Navab Safavi psychiatric Center during a period of six months. The onset and course of syndrome, types of drugs prescribed, and the variety of symptoms, were studied. Results showed that early diagnosis of the syndrome, cessation of neuroleptic drugs, and classical treatment were efective in saving the lives of 3 out of 5 patients. There was also a correlation between dosage of the drugs and the incidence of the syndrome.

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