Objectives: The aim of the present study was to assess the rate of personality disorders and coping strategies in female sex-workers. Method: In this observational cross-sectional study 30 female sex-workers who were selected using convenience sampling, completed the Structured Clinical Interview DSM-IV axis II disorders (SCID-II) and Billings Coping Style Questionnaire. Data were analyzed using descriptive statistics. Results: The findings showed a prevalence of 90% for personality disorders, with passive- aggressive personality disorder having the highest prevalence of 53.3%. Also, schizotypal personality disorder was not present in subjects. Among coping strategies, emotion-focused coping (56.7%) and somatization-focused coping (23.3%) were the most prevalent. Conclusion: Considering the high prevalence of personality disorder among female sex-workers and their high use of emotion-focused coping in confronting life events, training this group with coping and problem solving skills is recommended.