Objectives: The objective of the present study was to develop a Farsi version of Quality of Life in Epilepsy Inventory (QOLIE-89), and to assess its psychometric properties. Method: The Farsi version of QOLIE-89, which was developed through translation/ back translation, along with Beck Depression Inventory-Primary Care (BDI-PC) and General Health Questionnaire-12 (GHQ-12) was administered to 75 epilepsy patients in Alzahra and Ayatollah Kashani clinics in Isfahan. The reliability and internal consistency was assessed using Cronbach’s alpha, construct validity was assessed by correlation with GHQ-12 and BDI-PC, and discriminant validity was confirmed by comparing scores for known groups. Results: Cronbach’s alpha was 0.96 for the total score, and varied between 0.70 and 0.89 for subscales. High correspondence with GHQ-12 (r=0.63, p≥0.01) and BDI-PC (r=-0.55, p≥ 0.01) indicates construct validity, and differentiating between depressed versus non-depressed and drug-sensitive versus drug-resistant epilepsy patients, indicates discriminant validity of QOLIE-89. Conclusion: The results of the present study indicate that the Farsi version of QOLIE-89 has a good reliability and validity, and it could be used as a valid tool in clinical trials and research related to epilepsy.