Iranian Journal of Psychiatry and Clinical Psychology
مجله روانپزشكي و روانشناسي باليني ايران
IJPCP
Medical Sciences
http://ijpcp.iums.ac.ir
18
journal18
1735-4315
2228-7515
10.32598/ijpcp
fa
jalali
1382
2
1
gregorian
2003
5
1
8
4
online
1
fulltext
fa
مقایسه کارایی ترکیب فلوکستین- هالوپریدول با فلوکستین - دارونما در بیماران اختلال وسواسی- جبری
Comparison of Efficacy of Fluoxetine-Haloperidol vs. Fluoxetine-Placebo in Obsessive-Compulsive Patients
روانپزشکی و روانشناسی
Psychiatry and Psychology
پژوهشي اصيل
Original Research
<p class="2" style="MARGIN: 18pt 0cm 0pt"><strong><font face="Times New Roman" size="5">Abstract</font></strong></p><p class="MsoNormal" style="MARGIN: 0cm 0cm 0pt DIRECTION: ltr unicode-bidi: embed TEXT-ALIGN: left"><p><font face="Times New Roman" size="2"> </font></p></p><p class="a" style="MARGIN: 1pt 0cm"><font size="3"><font face="Times New Roman"><b>Objectives</b>: This study was designed to investigate the possibility of dopaminergic involve-ment in obsessive-compulsive patients (OCD). </font></font></p><p class="a" style="MARGIN: 1pt 0cm"><font size="3"><font face="Times New Roman"><b>Method:</b> This double-blind study compared <span style="LETTER-SPACING: -0.1pt">the efficacy of fluoxetine-haloperidol with that of </span><span style="LETTER-SPACING: -0.2pt">fluoxetine-placebo in two groups, each comprised of 12 subjects. These subjects with obsessive-</span><span style="LETTER-SPACING: -0.1pt">compulsive disorders were selected on the basis of DSM-IV diagnostic criteria they were asse- ssed by a demographic questionnaire and Yale-Brown Scale for evaluating obsessive-compul- </span>sive disorders.<b> <p></p></b></font></font></p><p class="a" style="MARGIN: 1pt 0cm"><font size="3"><font face="Times New Roman"><b>Findings:</b> The results showed that the response to treatment in haloperidol-fluoxetine group was somewhat better than the fluoxetine-placebo group from the first week of the study. The difference was significant at the third visit (end of fourth week). </font></font></p><p class="a" style="MARGIN: 1pt 0cm"><font size="3"><font face="Times New Roman"><b>Results:</b> In addition to serotonin neurotransmitter system, dopaminergic system may play a role in pathophysiology of obsessive-compulsive disorder.</font></font><span style="FONT-SIZE: 14pt"><p><font face="Times New Roman"> </font></p></span></p>
وسواسی- اجباری، فلوکستین، هالوپریدول
obsessive-compulsive disorder, fluoxetine, haloperidol
4
10
http://ijpcp.iums.ac.ir/browse.php?a_code=A-10-1-202&slc_lang=fa&sid=1
Gh.R.
Mirsepasi
غلامرضا
میرسپاسی
18003194753284600768
18003194753284600768
No
A.
Saliani
انوشه
سالیانی
E-mail: drsaliani@mail.com
18003194753284600769
18003194753284600769
Yes