TY - JOUR JF - ijpcp JO - IJPCP VL - 14 IS - 2 PY - 2008 Y1 - 2008/8/01 TI - Topiramate and Sodium Valproate as Adjunctive Therapy to Lithium Carbonate in Treatment of Bipolar Disorder in Adolescents: A Randomized Clinical Trial TT - توپیرامات و والپروات سدیم همراه با لیتیوم به‌عنوان درمان کمکی در اختلال دوقطبی نوجوانان: کارآزمایی بالینی تصادفی‌شده N2 - AbstractObjectives: In this study the effect of topiramate as adjunctive therapy to lithium on mood disorder in adolescents is compared to that of sodium valproate.Method: In a randomized clinical trial, 30 adolescents with bipolar mood disorder in the manic or mixed phase were treated with either topiramate or sodium valproate. All participants had either not responded adequately to a 4 to 6 week period of treatment with lithium carbonate, or had relapsed after a period of remission and needed additional mood-stabilizing drug. Responses were evaluated using Young Mania Rating Scale, Clinical Global Impression Scale and Children Global Assessment Scale.Results: Many of the demographic properties of both groups were similar. In each group the mean of the decrease in symptoms and degree of remission were significant (p SP - 122 EP - 130 AU - Mahmoudi-gharaei, Javad AU - Alaghband-rad, Javad AU - Faridhoseini, Farhad AU - Mohammadi, Mohammad Reza AU - Tehranidoost, Mahdi AU - Shahrivar, Zahra AU - Ghaeli, Padideh AU - Faghihi, Toktam AD - KW - bipolar disorder KW - adolescents KW - mood stabilizer KW - sodium valproate KW - topiramate KW - lithium KW - mania UR - http://ijpcp.iums.ac.ir/article-1-461-en.html ER -