RT - Journal Article T1 - A Comparison of the Effects of Typical and Atypical Antipsychotics on Inducing Obsessive-Compulsive Symptoms in Patients with Schizophrenia JF - ijpcp YR - 2008 JO - ijpcp VO - 13 IS - 4 UR - http://ijpcp.iums.ac.ir/article-1-351-en.html SP - 328 EP - 334 K1 - typical antipsychotics K1 - atypical antipsychotics K1 - obsessive-compulsive symptoms K1 - schizophrenia AB - AbstractObjectives: The effects of typical and atypical antipsychotics on inducing obsessive-compulsive symptoms in patients with schizophrenia were compared in this study. Method: In a comparative-descriptive study 64 patients with schizophrenia (32 patients in typical antipsychotic group and 32 patients in atypical antipsychotic group) were investigated. All patients with a confirmed diagnosis of schizophrenia based on Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I), underwent Yale-Brown Obsessive Compulsive Scale (Y-BOCS) and Brief Psychiatric Rating Scale (BPRS) at the beginning, as well as three and six weeks after treatment. Data were analyzed using descriptive statistics, repeated measures analysis of variance, and t-test. Results: In the group receiving typical antipsychotics, mean Y-BOCS scores were 2.40, 2.30, and 2.18 at the beginning, at three weeks and at six weeks after treatment respectively. Also, in the group receiving atypical antipsychotics Y-BOCS scores were 4.12, 4.46, and 4.53 at the beginning, at three weeks and at six weeks after treatment respectively. The difference of Y-BOCS scores in the two groups receiving typical and atypical antipsychotics was close to significance before treatment, and significant at three and six weeks after treatment (p LA eng UL http://ijpcp.iums.ac.ir/article-1-351-en.html M3 ER -