Volume 11, Issue 1 (5-2005)                   IJPCP 2005, 11(1): 24-30 | Back to browse issues page

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Khosropoor M, Ashkani H. Comparison of Latent Inhibition Mechanisms before and after Drug Therapy in Patients with Schizophrenia. IJPCP. 2005; 11 (1) :24-30
URL: http://ijpcp.iums.ac.ir/article-1-81-en.html
1- , E-mail: khosropoor@sums.ac.ir
Abstract:   (10106 Views)


Introduction: This study was aimed to compare the latent inhibition mechanisms (LI) in patients at the acute phase of schizophrenia with the patients whose symptoms were controlled by antipsy- chotic medications.

Method: LI was evaluated using visual and auditory stimuli in three groups: The first group (n=30) included the patients at the acute psychotic phase that did not take any medication. The second group (n=35) were the patients whose symptoms were controlled by antipsychotic drugs. The third group (n=31) were normal controls with no history of schizophrenia. The error score in learning in the testing phase was regarded as a dependent variable.

Results: The error scores in schizophrenia patients (acute phase and stable patients) were signifi-cantly higher as compared to the control group. The expected effect of LI was not observed in stable schizophrenia patients.

Conclusion: Our results did not show an association between LI and the phases of schizophrenia. It seems that patient's unfamiliarity with the testing technology has influenced the findings.

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Type of Study: Original Research | Subject: Psychiatry and Psychology
Received: 2007/03/25

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