Volume 8, Issue 4 (5-2003)                   IJPCP 2003, 8(4): 4-10 | Back to browse issues page

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Mirsepasi G, Saliani A. Comparison of Efficacy of Fluoxetine-Haloperidol vs. Fluoxetine-Placebo in Obsessive-Compulsive Patients. IJPCP. 2003; 8 (4) :4-10
URL: http://ijpcp.iums.ac.ir/article-1-210-en.html
1- , E-mail: drsaliani@mail.com
Abstract:   (14654 Views)



Objectives: This study was designed to investigate the possibility of dopaminergic involve-ment in obsessive-compulsive patients (OCD).

Method: This double-blind study compared the efficacy of fluoxetine-haloperidol with that of fluoxetine-placebo in two groups, each comprised of 12 subjects. These subjects with obsessive-compulsive disorders were selected on the basis of DSM-IV diagnostic criteria they were asse- ssed by a demographic questionnaire and Yale-Brown Scale for evaluating obsessive-compul- sive disorders.

Findings: The results showed that the response to treatment in haloperidol-fluoxetine group was somewhat better than the fluoxetine-placebo group from the first week of the study. The difference was significant at the third visit (end of fourth week).

Results: In addition to serotonin neurotransmitter system, dopaminergic system may play a role in pathophysiology of obsessive-compulsive disorder.


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Type of Study: Original Research | Subject: Psychiatry and Psychology
Received: 2007/10/29

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